Lithium, Inositol and Mitochondria.
The inositol depletion hypothesis, introduced by Berridge et al., suggested that the mood-stabilizing effect of the drug is mediated by its inhibitory effect on several enzymes in the phosphatidylinositol (PI) cycle, mainly an uncompetitive inhibition of inositol monophosphatase (IMPase). Berridge et al. proposed that inhibition of