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Monthly Archives: October 2018

Microglia And Bipolar.

 Recent investigations suggest that microglia, the resident immune cells of the brain, provide a physiological link between the serotonin system and the GSK-3β/Wnt pathway through neuroinflammation. In clinical practice, patients that fail to respond to an optimized regimen of mood stabilizers tend to respond to

Lamotrigine And Bipolar Depression.

Lamotrigine is an anticonvulsant approved by the US Food and Drug Administration for maintenance mood stabilization of bipolar I disorder. Its acute antidepressant properties are recognized increasingly, both through meta-analysis and placebo-controlled evaluation. The anticonvulsant activity of lamotrigine is thought to be mediated by voltage-dependent